Then last march my random bouts of anxiety and panic attacks became crippling. Sertraline is a selective serotonin reuptake inhibitor that is approved by the u.s. Zoloft First Week Side Effects Risk Factors Optum Perks Blog Zoloft takes around two to six weeks to show positive symptoms in the body. How long for zoloft to work for panic attacks . A smaller percentage of zoloft users may require more than 8 weeks to notice an effect from the medication. My doctor said it can take up to 9 weeks. I was taking 50 mg of zoloft about 8 years ago, it took 3 1/2 weeks to start working. However, zoloft 25 mg won’t do much good to patients with severe and panic level anxiety. “for the last 12 years i have experienced anxiety however i have always been able to cope without medication. In case you skip a dose, take it as soon as you remember. So one option your doctor can consider is adding a benzodiazepine until the zoloft takes effect weeks later. How long does it take for z...